San Francisco 49ers at Indianapolis Colts

Monday, December 22, 2025 · Week 16 · Watch Highlights

SF San Francisco 49ers 48 Winner
at
IND Indianapolis Colts 27
Total points 75 Margin 21 Kickoff 20:15 Referee Ron Torbert

Lucas Oil Stadium · closed · fieldturf

SF QB Brock Purdy IND QB Philip Rivers SF HC Kyle Shanahan IND HC Shane Steichen

Box score

SF IND
Total yards 440 335
Passing yards 295 277
Rushing yards 145 58
First downs 28 17
Passing TDs 5 2
Rushing TDs 0 1
Interceptions thrown 1 1
Fumbles lost 0 0
Sacks allowed 1 2
Completions / attempts 25 / 34 23 / 36

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